Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors
نویسندگان
چکیده
منابع مشابه
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.
AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, are involved in regulating cell cycle progression and cell death. Both cell cycle arrest and induction of apoptosis are mediated in part by transcriptional regulation of p27(kip1). Here we show that the Forkheads AFX (FOXO4) and FKHR-L1 (FOXO3a) also directly c...
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The FoxO forkhead transcription factors FoxO4 (AFX), FoxO3a (FKHR.L1), and FoxO1a (FKHR) represent important physiological targets of phosphatidylinositol-3 kinase (PI3K)/protein kinase B (PKB) signaling. Overexpression or conditional activation of FoxO factors is able to antagonize many responses to constitutive PI3K/PKB activation including its effect on cellular proliferation. It was previou...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2002
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.22.7.2025-2036.2002